题目：Multifunctional Semiconducting Polymer Dots for Imaging and Therapy

报告人：Changfeng Wu（Southern University of Science and Technology）

主持人：李向平研究员

时间：2017年4月11日下午3：30

地点：曾宪梓科学馆405会议室

报告摘要：

In this presentation, I will present several new types of polymer dots (Pdot) for biological imaging and phototherapy. The hydrophobic semiconductor polymers tend to form small, stable and densely-packed Pdots. The large absorption cross section, high fluorescence quantum yields, and good biocompatibility are promising for biological imaging in vitro and in vivo. We showed that the Pdots coated with a cell penetrating peptide had remarkable endocytic uptake efficiency for stem cell labeling as compared to carboxyl Pdots.  The Pdot-labeled stem cells can be traced for 15 generations in vitro and tracked over weeks in vivo after tail-vein injection.   For PDT applications, incorporation of photosensitizer inside the Pdots can amplify singlet-oxygen generation by efficient energy transfer. We developed Pdot photosensitizers and then systematically characterized the spectroscopic properties, which showed efficient singlet oxygen generation amplified by inter-particle energy transfer. The effectiveness of Pdots as PDT photosensitizer was demonstrated by in vitro assay, which indicate that the Pdots are able to damage cancer cells under low Pdot concentration and light dose.  Moreover, the PDT effect of the Pdots was further investigated in vivo with tumor-bearing mice model, and the xenograft tumors were significantly inhibited or eradicated in certain cases.

报告人简介：

吴长锋，获得国家自然科学优秀青年基金，中国生物医学工程学会生物光子学分会委员。在国际上率先开展了用半导体聚合物制备荧光量子点 (Polymer Dot)的研究，在聚合物量子点的制备表征、能量传递、单粒子荧光、性能调控和生物光学成像等方面开展了系统研究。迄今共发表SCI收录论文105篇，其中第一/通讯作者43篇。在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Mater.、ACS Nano等影像因子>10的专业权威期刊上发表论文19篇，其中第一/通讯作者为10篇。被包括Nature、Science、Nature子刊、Chemical Reviews、Chemical Society Reviews在内的学术期刊总共引用5000多次，其中单篇引用超过100次的论文15篇，当前H因子为35 (Google Scholar)。

欢迎广大师生参加！

光子技术研究院

2017年4月7日