个人简介

  广东“特支计划”青年拔尖人才、“暨南英才”计划杰出青年第一层次

  黄赟赟，女，研究员，博士生导师。研究方向：光纤传感，生物光子学，诊疗一体化

  入选广东省“特支计划” 青年拔尖人才、“暨南英才计划杰出青年”。从事超灵敏光纤生物传感器研究十余年，聚焦疾病诊疗重大需求，建立了光纤生化传感器界面增敏机制和治疗功能集成方法。主持国家自然科学基金等各类项目10余项；以一作/通讯作者在Science Advances、Light、Advanced Materials等期刊发表SCI论文34篇，在本领域权威期刊撰写特邀综述，多篇文章被遴选为当年Hot Paper和封面文章，总引用2700余次；任“广东省医疗行业协会超声医学创新与发展管理分会”委员、本领域权威期刊《Sensors》客座编辑、Interdisciplinary Medicine期刊青年编委、全国学术会议专题委员；入选2025年度全球前2%顶尖科学家年度榜。

承担科研项目及人才项目

人才项目4项：广东省特支计划青年拔尖人才

             “暨南英才计划”杰出青年（第一层次）

             暨南大学“双百英才计划”暨南杰青（第二层次）

             暨南大学“优秀青年教师”支持计划（第二层次）

代表性论文

(1) Hongtao Li, Yunyun Huang*, Guanhua Hou, Aoxiang Xiao, Pengwei Chen, He Liang, Yugang Huang, Xiaotian Zhao, Lili Liang, Xinhuan Feng, Bai-Ou Guan*. Single-molecule detection of biomarker and localized cellular photothermal therapy using an optical microfiber with nanointerface. Science Advances, 2019, 5, aax4659 （Science子刊）

(2) Yunyun Huang*#, Jiaxuan Liang#, Haotian Wu, Pengwei Chen, Aoxiang Xiao, Bai-Ou Guan*. Microscale insight into the proton concentration during electrolytic reaction via an optical microfiber: potential for microcurrent monitoring by a dielectric probe. Light: Science and Applications, 2025, 14, 73.

(3) Yunyun Huang*#, Pengwei Chen#, Luyan Zhou, Jiaying Zheng, Haotian Wu, Jiaxuan Liang, Aoxiang Xiao, Jie Li, Bai-Ou Guan*. Plasmonic Coupling on An Optical Microfiber Surface: Enabling Single‐Molecule And Noninvasive Dopamine Detection. Advanced Materials, 2023, 35, 2304116. (IF: 29.4)

(4) Haotian Wu#, Pengwei Chen#, Xundi Zhan, Kaiyue Lin, Tao Hu, Aoxiang Xiao, Jiaxuan Liang, Yugang Huang, Yunyun Huang*, Bai-Ou Guan*. Marriage of a Dual‐Plasmonic Interface and Optical Microfiber for NIR‐II Cancer Theranostics. Advanced Materials, 2024, 36, 2310571. (IF: 29.4)

(5) Pengwei Chen#, Haotian Wu#, Yajing Zhao#, Lv Zhong, Yujiao Zhang, Xundi Zhan, Aoxiang Xiao, Yunyun Huang*, Hong Zhang*, Bai-Ou Guan*. Quantitative Assessment of Fungal Biomarkers in Clinical Samples via an Interface‐Modulated Optical Fiber Biosensor. Advanced Materials, 2024, 2312985. (IF: 29.4)

(6) Yunyun Huang*#, Caini Mou#, Jiaxuan Liang#, Jiaxin Wan, Pengwei Chen, Bai-Ou Guan*. Operando decoding of surface chemical and thermal events in photoelectrocatalysis via a lab-around-microfiber sensor. Advanced Science, 2024, 11, 2310264.

(7) Pengwei Chen, Xinyu Zhang, Xundi Zhan, Yunyun Huang*, Hatotian Wu, Chenghao Zhao, Anding Xu*, Bai-Ou Guan*. Single-molecule amplification-free detection of nucleic acid biomarkers from body fluids via an optical microfiber with a nanointerface. Nano Letters, 2025, 25, 2978–2987.

(8) Pengwei Chen, Haotian Wu, Lin Liang, Tao Hu, Yunyun Huang*, Zhen Lin, Hao Wu, Bai-Ou Guan*. All‐in‐one optical microfiber with an interface for MRSA in biofilms: Integrating rapid quantitative analysis and synergistic antimicrobial therapy. InfoMat 2025, 7, e70023.

(9) Pengwei Chen, Kaiyue Lin, Tao Hu, Haotian Wu, Xundi Zhan, Chenghao Zhao, Yunyun Huang*, Anding Xu*, Bai-Ou Guan*. Portable Multifunctional Optical Microfiber Biosensor for Ultrasensitive Detection, Cell Lysis and Efficient Intracellular microRNA Analysis. Advanced Fiber Materials 2025, 7, 1462.

(10) Aoxiang Xiao, Xiaolan Wu, Jiaying Zheng, Yunyun Huang*, Anding Xu*, Bai-Ou Guan*. Sensitivity evaluation of an optical microfiber featuring interfaces with various gold nanoparticle morphologies: Application to the GFAP detection. Biosensors and Bioelectronics, 2025, 268, 116901.

(11) Wei Cui#, Aoxiang Xiao#, Canrong Luo, Xiaolan Wu, Jiaying Zheng, Pengwei Chen, Jiaxuan Liang, Haotian Wu, Bai-Ou Guan, Yunyun Huang*. Bimetallic interface on an optical microfiber nucleic acid sensor: Early detection in body fluids. Chemical Engineering Journal, 2024, 490, 151376.

(12) Hongtao Li, Yunyun Huang*, Chaoyan Chen, Aoxiang Xiao, Guanhua Hou, Yugang Huang, Xinhuan Feng, Bai-Ou Guan*. Real-time cellular cytochrome c monitoring through an optical microfiber: enabled by a silver-decorated graphene nanointerface. Advanced Science, 2018, 5, 1701074. (IF: 15.8)

(13) Yunyun Huang*#, Jaixuan Liang#, Pengwei Chen, Jiaxin Wan, Haotian Wu, Xiaolan Wu, Aoxiang Xiao, Bai-Ou Guan*. Fiber-Optic Microfiber: Tracking Activity Enhancement and Suppression of Heterogeneous Photocatalysts. Advanced Fiber Materials, 2023, 5, 527-542. (IF: 16.1)

(14) Yunyun Huang, Aoxiang Xiao, Guanhua Hou, Hongtao Li, Tuan Guo, Bai-Ou Guan*. Photocatalysis in an evanescent field: an in situ approach to studying photocatalytic performance by tracing interfacial refractive index changes and kinetics. Journal of Materials Chemistry A, 2018, 6, 20513-20522. (JMCA 2018 HOT PAPER, IF: 10.7)

(15) Yunyun Huang^#, Pengwei Chen^#, He Liang, Aoxiang Xiao, Shengkang Zeng, Bai-Ou Guan*. Nucleic acid hybridization on a plasmonic nanointerface of optical microfiber enables ultrahigh-sensitive detection and potential photothermal therapy. Biosensors and Bioelectronics, 2020, 156, 112147.（IF：10.2）

(16) Pengwei Chen, Yunyun Huang*, Ye Bo, He Liang, Aoxiang Xiao, Bai-Ou Guan*. 3D nanointerface enhanced optical microfiber for real-time detection and sizing of single nanoparticles. Chemical Engineering Journal, 2021, 407, 127143. (IF: 10.6)

(17) Aoxiang Xiao#, Jiaying Zheng#, Xiaolan Wu#, Wei Cui, Pengwei Chen, Jiaxuan Liang, Junyang Zhong, Yugang Huang, Yunyun Huang*, Bai-Ou Guan*. Ultrasensitive Detection and Cellular Photothermal Therapy via a Self‐Photothermal Modulation Biosensor. Advanced Optical Materials, 2023, 11, 2202711.

(18) He Liang#, Luyan Zhou#, Pengwei Chen#, Jaiying Zheng, Yunyun Huang*, Jiaxuan Liang, Junyang Zhong, Yugang Huang, Mingguang Yu, Bai-Ou Guan*. Optical Microfiber with a Gold Nanorods–Black Phosphorous Nanointerface: An Ultrasensitive Biosensor and Nanotherapy Platform. Analytical Chemistry 2022, 94, 8058-8065.（一区）

(19) Aoxiang Xiao, Yunyun Huang*, Jiaying Zheng, Pengwei Chen, Bai-Ou Guan. An optical microfiber biosensor for CEACAM5 detection in serum: sensitization by a nanosphere interface. ACS Applied Materials & Interfaces, 2020, 12, 1799-1805.（一区）

(20) Yunyun Huang, Tuan Guo, Zhuang Tian, Bo Yu, Mingfei Ding, Xiangping Li, Bai-Ou Guan*. Non-radiation cellular thermometry based on interfacial thermally induced phase transformation in polymer coating of optical microfiber. ACS Applied Materials Interfaces, 2017, 9, 9024-9028. (一区)

(21) Yunyun Huang, Mingfei Ding, Tuan Guo*, Dejiao Hu, Yaoyu Cao, Long Jin, Bai-Ou Guan*. A fiber-optic sensor for neurotransmitters with ultralow concentration: near-infrared plasmonic electromagnetic field enhancement using raspberry-like meso-SiO₂ nanospheres. Nanoscale, 2017, 9, 14929-14936. (一区)

(22) Yunyun Huang, Aoxiang Xiao, Guanhua Hou, Hongtao Li, Pengwei Chen, Chaoyan Chen, Bai-Ou Guan*. Impact of MoS₂ supporting interface on the photothermal-induced deformation of gold nanoshells: tracks through an optical microfiber. 2D Materials 2019, 6, 045007.（一区）

(23) Yunyun Huang, Yujie Chen, Chenglong Hu, Bin Zhang, Ting Shen, Xudong Chen*, Ming Qiu Zhang*. `Bridge` dffect of CdS nanoparticles in the interface of graphene-polyaniline composites. Journal of Materials Chemistry, 2012, 22, 10999-11002. (一区)

(24) Yunyun Huang, Mingfei Ding, Tuan Guo, Ning Zhang, Zhuang Tian, Bai-Ou Guan*. Ultrasensitive and label-free detection of γ-aminobutyric acid using fiber-optic interferometric sensors funxtionalized with size-selective molecular sieve arrays. Sensors and Actuators B: Chemical, 2017, 244, 934-940. (一区)

(25) Wanjun Hu, Yunyun Huang*, Chaoyan Chen, Yuke Liu, Tuan Guo*, Bai-Ou Guan. Highly sensitive detection of dopamine using a graphene functionalized plasmonic fiber-optic sensor with aptamer conformational amplification. Sensors and Actuators B: Chemical, 2018, 264, 440-447. (一区)

(26) Wei Cui#, Aoxiang Xiao#, Jiaying Zheng, Pengwei Chen, Jiaxuan Liang, Yunyun Huang*, Bai-Ou Guan*. Facile Preparation of Monodisperse Silver Nanorods with Tunable Plasmon Resonances in the Near-Infrared Region: Implications for SERS-Based Sensing. ACS Applied Nano Materials, 2023, 6, 6345-6353.

(27) Yunyun Huang, Chaoyan Chen, Hongtao Li, Aoxiang Xiao, Tuan Guo, Bai-Ou Guan*. Insight into the local near-infrared photothermal dynamics of graphene oxide functionalized polymers through optical microfibers. Physical Chemistry Chemical Physics, 2018, 20, 5256-5263.

(28) Jun Zhou, Yunyun Huang*, Chaoyan Chen, Aoxiang Xiao, Tuan Guo, Bai-Ou Guan. Improved detection sensitivity of γ-aminobutyric acid based on graphene oxide interface on an optical microfiber. Physical Chemistry Chemical Physics, 2018, 20, 14117-14123.

(29) Yunyun Huang, Bo Yu, Tuan Guo, Bai-Ou Guan*. Ultrasensitive and in situ DNA detection in various pH environments based on a microfiber with a graphene oxide linking layer. RSC Advances, 2017, 7, 13177-13183.

(30) Yunyun Huang, Zhuang Tian, Li-Peng Sun, Dandan Sun, Jie Li, Yang Ran, Bai-Ou Guan*. High-sensitivity DNA biosensor based on optical fiber taper interferometer coated with conjugated polymer tentacle. Optics Express, 2015, 23(21), 26962-26968. 

(31) Bo Yu, Yunyun Huang*, Jun Zhou, Tuan Guo, and Bai-Ou Guan. Understanding the pH-dependent interaction between graphene oxide and single-stranded DNA through a fiber-optic interferometer. Physical Chemistry Chemical Physics, 2016, 18, 32266-32271. 

(32) Bo Yu, Yunyun Huang*, Jun Zhou, Tuan Guo, Bai-Ou Guan. Real-time, in-situ analysis of silver ions using nucleic acid probes modified silica microfiber interferometry. Talanta, 2017, 165, 245-250. 

(33) Yunyun Huang, Wensheng Lin, Kan Chen, Wenkai Zhang, Xudong Chen*, Ming Qiu Zhang*. Thermoresponsive fluorescence of graphene-polymer composite based on local surface plasmons resonance effect. Physical Chemistry Chemical Physics, 2014, 16, 11584-11589.

(34) Yunyun Huang, Xudong Chen*, Ming Qiu Zhang*. Reversible surface wettability conversion of graphene films: optically controlled mechanism. Journal of Materials Science, 2014, 49(8), 3025-3033.